Abstract | BACKGROUND:
Melasma is an acquired symmetric hypermelanosis characterised by irregular light to gray-brown macules on sun-exposed skin with a predilection for the cheeks, forehead, upper lip, nose and chin. The management of melasma is challenging and requires meticulous use of available therapeutic options. AIMS: To compare the therapeutic efficacy of low-fluence Q-switched Nd: YAG laser (QSNYL) with topical 20% azelaic acid cream and their combination in melasma in three study groups of 20 patients each. MATERIALS AND METHODS: Sixty Indian patients diagnosed as melasma were included. These patients were randomly divided in three groups (group A = 20 patients of melasma treated with low-fluence QSNYL at weekly intervals, group B = 20 patients of melasma treated with twice daily application of 20% azelaic acid cream and group C = 20 patients of melasma treated with combination of both). Study period was of 12 weeks each. Response to treatment was assessed using melasma area and severity index score. STATISTICAL ANALYSIS: The statistical analysis was done using Chi-square test, paired and unpaired student t-test. RESULTS: Significant improvement was recorded in all the three groups. The improvement was statistically highly significant in Group C as compared to group A (P < 0.001) and group B (P < 0.001). CONCLUSIONS: This study shows the efficacy of low-fluence QSNYL, topical 20% azelaic acid cream and their combination in melasma. The combination of low-fluence QSNYL and topical 20% azelaic acid cream yields better results as compared to low-fluence QSNYL and azelaic acid alone.
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Authors | Charu Bansal, Hira Naik, Hemanta K Kar, Amrita Chauhan |
Journal | Journal of cutaneous and aesthetic surgery
(J Cutan Aesthet Surg)
Vol. 5
Issue 4
Pg. 266-72
(Oct 2012)
ISSN: 0974-2077 [Print] India |
PMID | 23378709
(Publication Type: Journal Article)
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