Clindamycin phosphate 1.2% and tretinoin 0.025% gel for rosacea: summary of a placebo-controlled, double-blind trial.

Abstract	Rosacea is a common, chronic, and poorly understood dermatological condition characterized by an inflammatory component composed of papules and pustules and a vascular component composed of flushing and erythema. Current treatment options include topical, systemic, and light-based methods, each of which focuses on either the inflammatory or the vascular component. Retinoids are not routinely indicated as treatment because of the common conception that they would be too inflammatory for the sensitive rosacea patient. However, photodamage may play a role in rosacea and tretinoin is well-known to repair photodamage. Thirty rosacea subjects were enrolled to assess their response to the use of clindamycin phosphate 1.2% and tretinoin 0.025% gel (ZIANA; Medicis Pharmaceutical Corporation, Scottsdale, AZ) for a period of 12 weeks. The results showed a dramatic decrease in pustules and papules without any significant inflammation or overall intolerance. No improvement in facial redness was achieved. Based on our results, more investigation of topical retinoids for rosacea treatment is prudent.
Authors	Scott A Freeman, Summer D Moon, James M Spencer
Journal	Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 11 Issue 12 Pg. 1410-4 (Dec 2012) ISSN: 1545-9616 [Print] United States
PMID	23377509 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References	Anti-Bacterial Agents Drug Combinations Gels Irritants Keratolytic Agents Clindamycin Tretinoin
Topics	Administration, Topical Adult Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use) Clindamycin (administration & dosage, adverse effects, therapeutic use) Diagnostic Self Evaluation Double-Blind Method Drug Combinations Female Gels Humans Irritants Keratolytic Agents (administration & dosage, adverse effects, therapeutic use) Male Middle Aged Rosacea (drug therapy, pathology) Skin (pathology) Skin Pigmentation (drug effects) Tretinoin (administration & dosage, adverse effects, therapeutic use) Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!