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miR-29b moulds the tumour microenvironment to repress metastasis.

Abstract
Tumour cells are influenced by their microenvironment, which can promote uncontrolled growth, invasion and metastasis. The GATA3 transcription factor is now shown to regulate the tumour microenvironment by inducing the expression of miR-29b in cancer cells. This microRNA in turn inhibits the expression of genes involved in angiogenesis and extracellular matrix signalling and remodelling to suppress metastasis.
AuthorsSonia A Melo, Raghu Kalluri
JournalNature cell biology (Nat Cell Biol) Vol. 15 Issue 2 Pg. 139-40 (Feb 2013) ISSN: 1476-4679 [Electronic] England
PMID23377028 (Publication Type: Journal Article, Comment)
Chemical References
  • GATA3 Transcription Factor
  • GATA3 protein, human
  • Gata3 protein, mouse
  • MIRN29 microRNA, mouse
  • MIRN29a microRNA, human
  • MicroRNAs
Topics
  • Animals
  • Breast Neoplasms (metabolism)
  • Cell Movement
  • Female
  • GATA3 Transcription Factor (metabolism)
  • Humans
  • MicroRNAs (metabolism)
  • Tumor Microenvironment

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