A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies.

Abstract

Uncaria rhynchophylla (Miq.) Jacks, Rubiaceae, is one of the original plants of the important Chinese crude drug, Gou-teng, mainly used for the treatment of convulsion, hypertension, epilepsy, eclampsia, and cerebral diseases. The pharmacological activities of this plant are related to the presence of active compounds predominantly indole alkaloids. In this article, we have reviewed some reports about the pharmacological activities of the main indole alkaloids isolated from U. rhynchophylla. This review paper will contribute to the studies on the chemistry, safety and quality control of medicinal preparations containing Uncaria species.

• Authors: Andre Ndagijimana, Xiaoming Wang, Guixiang Pan, Fan Zhang, Hong Feng, Olajide Olaleye
• Journal: Fitoterapia (Fitoterapia) Vol. 86 Pg. 35-47 (Apr 2013) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 23376412 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Anticonvulsants
• Antihypertensive Agents
• Drugs, Chinese Herbal
• Indole Alkaloids
• Neuroprotective Agents
• gou-teng

Topics

• Animals
• Anticonvulsants (pharmacology)
• Antihypertensive Agents (pharmacology)
• Drugs, Chinese Herbal (chemistry, pharmacology)
• Humans
• Indole Alkaloids (isolation & purification, pharmacology)
• Neuroprotective Agents (pharmacology)
• Uncaria (chemistry)