Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide.

Abstract

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare subtype of localized cutaneous amyloidosis and can be associated with various connective tissue disorders. It can be difficult to treat and past therapies include surgical excision, dermabrasion, electrodessication and curettage, cryotherapy and laser therapy. We present a case of a middle-aged woman with PLCNA associated with CREST (calcinosis, Raynaud phenomenon, oesophageal motility disorders, sclerodactyly and telangiectasia) syndrome and Sjögren's syndrome responding to cyclophosphamide with no new amyloid deposits and resolution of skin ulceration after many years of resistance to drug therapy. It is important to monitor these patients for progression into systemic amyloidosis.

• Authors: Philip L Tong, William A Walker, Ross J Glancy, Julian P Cooney, Kurt Gebauer
• Journal: The Australasian journal of dermatology (Australas J Dermatol) Vol. 54 Issue 1 Pg. e12-5 (Feb 2013) ISSN: 1440-0960 [Electronic] Australia
• PMID: 23373889 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2011 The Authors. Australasian Journal of Dermatology © 2011 The Australasian College of Dermatologists.

Chemical References

• Immunosuppressive Agents
• Cyclophosphamide

Topics

• Amyloidosis (diagnosis, drug therapy, etiology)
• Cyclophosphamide (therapeutic use)
• Female
• Humans
• Immunosuppressive Agents (therapeutic use)
• Middle Aged