Abstract | BACKGROUND: To better understand the role of human rhinovirus-associated wheeze as a risk factor for childhood recurrent wheezing, a cohort of young children experiencing their first wheezing episode was followed until school age. METHODS: All 111 hospitalized wheezing children (median age, 12 months) were initially participated in a randomized, double-blind, placebo-controlled, parallel trial on the efficacy of oral prednisolone. In this 7-yr follow-up, risk factors for recurrent wheezing were analysed, and then, the efficacy of prednisolone was evaluated overall and in pre-specified subgroups post-hoc. The main outcome was time to recurrent wheezing. RESULTS: The strongest independent risk factor for recurrent wheezing was rhinovirus detection (hazard ratio 3.54; 95% confidence interval 1.51-8.30) followed by sensitization (3.47; 1.55-8.30, respectively) age <1 yr (2.45; 1.29-4.65) and eczema (2.33; 1.11-4.90). Overall, prednisolone did not prevent recurrent wheezing. In subgroup analysis, prednisolone was associated with less recurrent wheezing in children affected by rhinovirus (0.32; 0.12-0.90, adjusted to sensitization, young age, viral aetiology and parental asthma) and/or with eczema (0.27; 0.08-0.87, adjusted respectively). CONCLUSIONS: Our data strengthen the role of rhinovirus-associated wheeze as an important risk factor for recurrent wheezing and asthma in young first-time wheezing children. Prospective randomized trials on the efficacy of corticosteroids in rhinovirus-associated early wheezing are warranted. (ClinicalTrials.gov number, NCT 00494624).
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Authors | Minna Lukkarinen, Heikki Lukkarinen, Pasi Lehtinen, Tytti Vuorinen, Olli Ruuskanen, Tuomas Jartti |
Journal | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
(Pediatr Allergy Immunol)
Vol. 24
Issue 3
Pg. 237-43
(May 2013)
ISSN: 1399-3038 [Electronic] England |
PMID | 23373881
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Chemical References |
- Glucocorticoids
- Prednisolone
|
Topics |
- Administration, Oral
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Glucocorticoids
(administration & dosage)
- Humans
- Infant
- Male
- Picornaviridae Infections
(complications)
- Prednisolone
(administration & dosage)
- Recurrence
- Respiratory Sounds
(drug effects, etiology)
- Rhinovirus
(drug effects)
- Risk
- Treatment Outcome
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