Possible interaction between SPPS and enalapril.

Abstract	A patient undergoing groin lymph node dissection with spinal and general anaesthesia was receiving enalapril to control hypertension. Infusion of stable plasma protein solution (Commonwealth Serum Laboratories, Australia) was associated with significant hypotension and flushing. A brief review of stable plasma protein solution and angiotensin converting enzyme inhibitor pharmacology is presented to provide a possible mechanism for these events. This mechanism implies that angiotensin converting enzyme inhibitor therapy is a relative contraindication to rapid SPPS infusion.
Authors	A J McKenzie
Journal	Anaesthesia and intensive care (Anaesth Intensive Care) Vol. 18 Issue 1 Pg. 124-6 (Feb 1990) ISSN: 0310-057X [Print] United States
PMID	2337234 (Publication Type: Case Reports, Journal Article)
Chemical References	Blood Proteins Plasma Substitutes stable plasma protein solution Enalapril
Topics	Aged Anesthesia, General Anesthesia, Spinal Blood Proteins Drug Interactions Enalapril Female Humans Lymph Node Excision Plasma Substitutes

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!