Abstract | OBJECTIVE: METHODS: Thermal and mechanical hyperalgesia was evoked in mouse knee joints by intraplantar injection of tumor necrosis factor α and intraarticular infusion of Freund's complete adjuvant, and the analgesic effects of cortistatin, administered centrally, peripherally, and systemically, were assessed. In addition, the effects of cortistatin on the production of nociceptive peptides and the activation of pain signaling were assayed in dorsal root ganglion cultures and in inflammatory pain models. The role of endogenous cortistatin in pain sensitization and perpetuation of chronic inflammatory states was evaluated in cortistatin-deficient mice. Finally, the effect of noxious/inflammatory stimuli in the production of cortistatin by the peripheral nociceptive system was assayed in vitro and in vivo. RESULTS: CONCLUSION:
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Authors | Maria Morell, Luciana Souza-Moreira, Marta Caro, Francisco O'Valle, Irene Forte-Lago, Luis de Lecea, Elena Gonzalez-Rey, Mario Delgado |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 65
Issue 5
Pg. 1390-401
(May 2013)
ISSN: 1529-0131 [Electronic] United States |
PMID | 23371349
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 by the American College of Rheumatology. |
Chemical References |
- GTP-Binding Protein alpha Subunits
- Ghrelin
- Neuropeptides
- Receptors, Ghrelin
- Receptors, Somatostatin
- Tumor Necrosis Factor-alpha
- cortistatin
- Somatostatin
- Freund's Adjuvant
- Calcitonin Gene-Related Peptide
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Topics |
- Analgesia
- Animals
- Arthritis
(chemically induced, drug therapy, metabolism)
- Calcitonin Gene-Related Peptide
(metabolism)
- Central Nervous System Sensitization
- Disease Models, Animal
- Drug Therapy, Combination
- Female
- Freund's Adjuvant
(administration & dosage, toxicity)
- GTP-Binding Protein alpha Subunits
(metabolism)
- Ghrelin
(metabolism, pharmacology)
- Hyperalgesia
(chemically induced, drug therapy, metabolism)
- Injections, Intra-Articular
- MAP Kinase Signaling System
(drug effects)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Neuropeptides
(deficiency, metabolism, pharmacology)
- Pain
(chemically induced, drug therapy, metabolism)
- Pain Threshold
- Protein Binding
- Receptors, Ghrelin
(metabolism)
- Receptors, Somatostatin
(metabolism)
- Somatostatin
(metabolism, pharmacology)
- Stifle
(drug effects, metabolism, physiopathology)
- Tumor Necrosis Factor-alpha
(toxicity)
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