Abstract | CONTEXT: OBJECTIVE: This study investigated the analgesic and anti-inflammatory properties of three compound derivatives from podophyllotoxin. MATERIALS AND METHODS: During a phytochemical study performed on Juniperus thurifera Linne (Cupressaceae) leaves, among other products, several cyclolignans, such as podophyllotoxin, deoxypodophyllotoxin, deoxypicropodophyllotoxin and thuriferic acid were isolated. These compounds, obtained afterwards through semisynthesis, were assayed as analgesic and anti-inflammatory agents. Additionally, the cytotoxic activity of thuriferic acid was evaluated in three cancer cell lines, P-388, A-549 and HT-29, and these data were compared with previous cytotoxicity results obtained for the other three compounds. RESULTS: CONCLUSION:
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Authors | Estela Guerrero, Andrés Abad, Gisela Montenegro, Esther Del Olmo, José Luis López-Pérez, Arturo San Feliciano |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 51
Issue 5
Pg. 566-72
(May 2013)
ISSN: 1744-5116 [Electronic] England |
PMID | 23363067
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents
- Antineoplastic Agents
- Carbazoles
- Drugs, Chinese Herbal
- Naphthalenes
- thuriferic acid
- deoxypodophyllotoxin
- Podophyllotoxin
- Indomethacin
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Topics |
- Analgesics
(chemistry, pharmacology)
- Animals
- Anti-Inflammatory Agents
(chemistry, pharmacology)
- Antineoplastic Agents
(chemistry, pharmacology)
- Carbazoles
(pharmacology)
- Cell Line, Tumor
- Disease Models, Animal
- Drugs, Chinese Herbal
- HT29 Cells
- Humans
- Indomethacin
(pharmacology)
- Inflammation
(drug therapy, pathology)
- Juniperus
(chemistry)
- Male
- Mice
- Naphthalenes
(pharmacology)
- Neoplasms
(drug therapy, pathology)
- Pain
(drug therapy, physiopathology)
- Plant Leaves
- Podophyllotoxin
(analogs & derivatives, pharmacology)
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