Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: In the early 2000s, a massive transfusion protocol (emphasizing aggressive use of fresh frozen plasma) coupled with hypotensive resuscitation and rapid hemorrhage control were implemented and refined at a busy level I trauma center in Houston, Texas, USA. These changes were associated with a 50% reduction in mortality in massive transfusion patients, and ACS virtually disappeared. SUMMARY: ACS is a modifiable link in the MOF cascade to death after severe shock. However, as ACS disappears, MOF is still occurring. Although fewer patients are dying of MOF, it remains the leading cause of prolonged ICU stays and long-term disability. This experience underscores the importance of ongoing epidemiologic characterization of postinjury MOF.
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Authors | Ernest A Gonzalez, Frederick A Moore |
Journal | Current opinion in critical care
(Curr Opin Crit Care)
Vol. 16
Issue 6
Pg. 570-4
(Dec 2010)
ISSN: 1531-7072 [Electronic] United States |
PMID | 23361130
(Publication Type: Editorial, Research Support, N.I.H., Extramural)
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Topics |
- Abdominal Injuries
(complications, mortality)
- Blood Transfusion
- Clinical Protocols
- Critical Illness
- Humans
- Intensive Care Units
- Intra-Abdominal Hypertension
(etiology, mortality, therapy)
- Multiple Organ Failure
(complications, etiology)
- Resuscitation
(methods)
- Risk Factors
- Shock, Hemorrhagic
(complications, etiology)
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