Application of poly-L-lactic acid nanosheet as a material for wound dressing.

Abstract

The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing.

• Authors: Shimpo Aoki, Manabu Kinoshita, Hiromi Miyazaki, Akihiro Saito, Toshinori Fujie, Keiichi Iwaya, Shinji Takeoka, Daizoh Saitoh
• Journal: Plastic and reconstructive surgery (Plast Reconstr Surg) Vol. 131 Issue 2 Pg. 236-240 (Feb 2013) ISSN: 1529-4242 [Electronic] United States
• PMID: 23357985 (Publication Type: Journal Article)

Chemical References

• Polyesters
• Polymers
• Lactic Acid
• poly(lactide)

Topics

• Animals
• Bandages
• Lactic Acid
• Male
• Mice
• Mice, Inbred C57BL
• Nanostructures
• Polyesters
• Polymers
• Wound Healing