Oral mucosal adhesive films containing royal jelly accelerate recovery from 5-fluorouracil-induced oral mucositis.

Abstract

Oral mucositis induced by chemotherapy or radiotherapy has an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes considerable morbidity. We evaluated the effect of royal jelly (RJ) on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combination of 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained in chitosan-sodium alginate film (RJ film). Films were attached to the oral mucosa and the healing process examined by measuring the area of mucositis, myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detection of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β). Furthermore, we evaluated the radical-scavenging activity of RJ and generation of keratinocyte growth factor from human periodontal ligament fibroblasts. RJ films (10%, 30%) significantly improved recovery from 5-FU-induced damage, reduced MPO activity and the production of pro-inflammatory cytokines. Additionally, RJ showed radical-scavenging activity. These data suggest that topical application of films that contain RJ had a healing effect on the severe oral mucositis induced by 5-FU and that the effect was caused by the anti-inflammatory or anti-oxidative activities of RJ.

• Authors: Shinichi Watanabe, Katsuya Suemaru, Kenshi Takechi, Hiroaki Kaji, Kimie Imai, Hiroaki Araki
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 121 Issue 2 Pg. 110-8 ( 2013) ISSN: 1347-8648 [Electronic] Japan
• PMID: 23357874 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adhesives
• Fatty Acids
• Free Radical Scavengers
• Interleukin-1beta
• Tumor Necrosis Factor-alpha
• Fibroblast Growth Factor 7
• Peroxidase
• royal jelly
• Fluorouracil

Topics

• Adhesives (administration & dosage)
• Animals
• Cheek (pathology)
• Cricetinae
• Fatty Acids (administration & dosage, pharmacology, therapeutic use)
• Fibroblast Growth Factor 7 (metabolism)
• Fluorouracil (adverse effects)
• Free Radical Scavengers (administration & dosage)
• Interleukin-1beta (metabolism)
• Mouth Mucosa (drug effects, metabolism, pathology)
• Peroxidase (metabolism)
• Stomatitis (chemically induced, drug therapy, pathology)
• Tumor Necrosis Factor-alpha (metabolism)