Abstract | BACKGROUND: METHODS: The -164T > C polymorphism was genotyped in a case-cohort study (193 incident myocardial infarction (MI) and 131 incident ischemic stroke (IS) cases and 1 978 non-cases) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study, comprising 27 548 middle-aged subjects. The Heinz Nixdorf Recall study (30 CVD cases and 1 188 controls) was used to replicate our findings. RESULTS: Genotype frequencies were not different between CVD and CVD free subjects (P = 0.79). We observed an interaction between the -164T > C polymorphism and total cholesterol levels in relation to future CVD. Corresponding stratified analyses showed a significant increased risk of CVD (HR(additve) = 1.38, 95% CI: 1.07 to 1.78) for individuals with cholesterol levels <200 mg/dL in the EPIC-Potsdam study. HR(additive) was 1.06, 95% CI: 0.33 to 3.40 for individuals in the Heinz Nixdorf Recall study. A borderline significant decrease in CVD risk was observed in subjects with cholesterol levels ≥ 200 mg/dL (HR(additve) = 0.77, 95% CI: 0.58 to 1.03) in the EPIC-Potsdam study. A similar trend was observed in the independent cohort (HR(additve) = 0.60, 95% CI: 0.29 to 1.25). CONCLUSIONS: Our study suggests an interaction between MTTP -164T > C functional polymorphism with total cholesterol levels. Thereby risk allele carriers with low cholesterol levels may be predisposed to an increased risk of developing CVD, which seems to be abolished among risk allele carriers with high cholesterol levels.
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Authors | Romina di Giuseppe, Sonali Pechlivanis, Eva Fisher, Maria Arregui, Beate Weikert, Sven Knüppel, Brian Buijsse, Andreas Fritsche, Stefan N Willich, Hans-Georg Joost, Heiner Boeing, Susanne Moebus, Cornelia Weikert |
Journal | BMC medical genetics
(BMC Med Genet)
Vol. 14
Pg. 19
(Jan 29 2013)
ISSN: 1471-2350 [Electronic] England |
PMID | 23356586
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carrier Proteins
- microsomal triglyceride transfer protein
- Cholesterol
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Topics |
- Brain Ischemia
(complications, genetics)
- Carrier Proteins
(genetics)
- Cholesterol
(blood)
- Cohort Studies
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Germany
(epidemiology)
- Humans
- Middle Aged
- Myocardial Infarction
(epidemiology, genetics)
- Polymorphism, Single Nucleotide
(genetics)
- Risk Factors
- Stroke
(etiology)
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