Abstract | STUDY DESIGN: Prospective study. OBJECTIVE: SUMMARY OF BACKGROUND DATA: Failure of fixation caused by loosening of PSs in osteoporosis is a problem in spinal surgery. Oral administration of bisphosphonate or intermittent injection of parathyroid hormone treatment increases bone mass and reduces the risk of osteoporotic vertebral fractures. Although these treatments may be factor in improving bone quality, a clinical study of the efficacy of bisphosphonate or parathyroid hormone for reducing PS loosening that addresses the quality of the bone marrow and pedicle cortex has not yet been reported. METHODS: RESULTS: At 12-month follow-up, the incidence of PS loosening was 7% to 13% in the teriparatide group, 13% to 26% in the risedronate group, and 15% to 25% in the control group. The incidence of PS loosening in the teriparatide group was significantly lower than that in the risedronate or the control group (P < 0.05). In contrast, the extent of PS loosening in the risedronate group was not significantly different from that in the control group (P > 0.05). CONCLUSION: Our findings suggest that administration of teriparatide increased the quality of the lumbar spine bone marrow and pedicle cortex.
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Authors | Seiji Ohtori, Gen Inoue, Sumihisa Orita, Kazuyo Yamauchi, Yawara Eguchi, Nobuyasu Ochiai, Shunji Kishida, Kazuki Kuniyoshi, Yasuchika Aoki, Junichi Nakamura, Tetsuhiro Ishikawa, Masayuki Miyagi, Hiroto Kamoda, Miyako Suzuki, Gou Kubota, Yoshihiro Sakuma, Yasuhiro Oikawa, Kazuhide Inage, Takeshi Sainoh, Masashi Takaso, Tomoaki Toyone, Kazuhisa Takahashi |
Journal | Spine
(Spine (Phila Pa 1976))
Vol. 38
Issue 8
Pg. E487-92
(Apr 15 2013)
ISSN: 1528-1159 [Electronic] United States |
PMID | 23354115
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Bone Density Conservation Agents
- Teriparatide
- Risedronic Acid
- Etidronic Acid
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Topics |
- Aged
- Aged, 80 and over
- Bone Density
(drug effects)
- Bone Density Conservation Agents
(therapeutic use)
- Bone Screws
- Etidronic Acid
(analogs & derivatives, therapeutic use)
- Female
- Humans
- Lumbar Vertebrae
(surgery)
- Middle Aged
- Osteoporosis, Postmenopausal
(drug therapy)
- Osteoporotic Fractures
(prevention & control)
- Prospective Studies
- Risedronic Acid
- Spinal Fusion
(instrumentation, methods)
- Teriparatide
(therapeutic use)
- Treatment Outcome
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