IgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis.

Abstract

This study has established the presence of IgM against S-nitrosylated proteins in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope (anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal rather than the result of ingress from serum. Two correlations during relapse: between CSF level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker.

• Authors: Charlotte Hvaring, Snezana Vujicic, Jan O Aasly, Douglas L Feinstein, Linda R White, Anne I Boullerne
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 256 Issue 1-2 Pg. 77-83 (Mar 15 2013) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 23351705 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Immunoglobulin G
• Immunoglobulin M
• S-Nitrosothiols
• S-nitrosocysteine
• Cysteine

Topics

• Adult
• Cysteine (analogs & derivatives, immunology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoglobulin G (blood, cerebrospinal fluid)
• Immunoglobulin M (blood, cerebrospinal fluid)
• Male
• Middle Aged
• Multiple Sclerosis, Relapsing-Remitting (blood, cerebrospinal fluid)
• S-Nitrosothiols (immunology)
• Statistics as Topic
• Young Adult