IgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis.

This study has established the presence of IgM against S-nitrosylated proteins in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope (anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal rather than the result of ingress from serum. Two correlations during relapse: between CSF level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker.
AuthorsCharlotte Hvaring, Snezana Vujicic, Jan O Aasly, Douglas L Feinstein, Linda R White, Anne I Boullerne
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 256 Issue 1-2 Pg. 77-83 (Mar 15 2013) ISSN: 1872-8421 [Electronic] Netherlands
PMID23351705 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Immunoglobulin G
  • Immunoglobulin M
  • S-Nitrosothiols
  • S-nitrosocysteine
  • Cysteine
  • Adult
  • Cysteine (analogs & derivatives, immunology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G (blood, cerebrospinal fluid)
  • Immunoglobulin M (blood, cerebrospinal fluid)
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting (blood, cerebrospinal fluid)
  • S-Nitrosothiols (immunology)
  • Statistics as Topic
  • Young Adult

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