[Experimental and clinicolaboratory evaluation of complex therapy efficacy in arboviral infections].

Abstract	Search for drugs efficient in prophylaxis and treatment of dangerous infections (especially arboviral ones) is rather actual, since no specific therapy is available. Many-year investigations of interferon inductors showed that they had immunomodulating, antiviral and antiinflammatory effects and were low toxic. The present study demonstrated that the protective effect was the following: Venezuelan equine encephalitis (VEE)--cycloferon > amixin = ridostin, Rift Valley fever (RVF)--cycloferon > amixin > ridostin, predator pox (PP)--cycloferon > amixin = ridostin, that was obvious that cycloferon was the most active agent in the treatment of VEE, RVF and PP, thus making it possible to acknowledge its priority in prophylaxis and therapy of dangerous viral infections (DVI). Ribavirin in combination with cycloferon solution or cycloferon tablets provided shorter periods of the fever, minimized the intoxication syndrome, promoted earlier resolution of hemorrhagic eruption and lowered the frequency of complications, which was in favour of the disease prognosis.
Authors	M G Romantsov, Kh M Galimzianov, O M Lokteva, A L Kovalenko, A V Stepanov
Journal	Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 57 Issue 7-8 Pg. 12-22 ( 2012) ISSN: 0235-2990 [Print] Russia (Federation)
PMID	23350190 (Publication Type: Case Reports, Journal Article, Randomized Controlled Trial)
Chemical References	Acridines Antiviral Agents Interferon Inducers RNA, Double-Stranded RNA, Fungal ridostin Ribavirin Tilorone 10-carboxymethyl-9-acridanone
Topics	Acridines (pharmacology, therapeutic use) Adolescent Adult Aged Animals Antiviral Agents (pharmacology, therapeutic use) Dengue (drug therapy, etiology) Encephalomyelitis, Venezuelan Equine (drug therapy, etiology) Female Hemorrhagic Fever, Crimean (drug therapy) Humans Interferon Inducers (pharmacology, therapeutic use) Ixodes (virology) Male Mice Middle Aged RNA, Double-Stranded (pharmacology, therapeutic use) RNA, Fungal (pharmacology, therapeutic use) Ribavirin (therapeutic use) Rift Valley Fever (drug therapy, etiology, transmission) Tilorone (therapeutic use) Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!