Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas.

Abstract

The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we observed for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacological inhibition decreased cell proliferation and induced apoptosis. The same results were observed with the SupT1 human T cell lymphoma line. In addition we observed an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL.

• Authors: Nadia Lounnas, Célia Rosilio, Marielle Nebout, Didier Mary, Emmanuel Griessinger, Zouhour Neffati, Johanna Chiche, Hergen Spits, Thijs J Hagenbeek, Vahid Asnafi, Sally-Ann Poulsen, Claudiu T Supuran, Jean-François Peyron, Véronique Imbert
• Journal: Cancer letters (Cancer Lett) Vol. 333 Issue 1 Pg. 76-88 (Jun 01 2013) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 23348702 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Carbonic Anhydrase Inhibitors
• PTEN Phosphohydrolase
• Pten protein, mouse
• Carbonic Anhydrases
• carbonic anhydrase XII

Topics

• Animals
• Apoptosis (drug effects)
• Carbonic Anhydrase Inhibitors (pharmacology)
• Carbonic Anhydrases (drug effects, genetics, physiology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Humans
• Hydrogen-Ion Concentration
• Lymphoma, T-Cell (drug therapy, enzymology)
• Mice
• PTEN Phosphohydrolase (physiology)