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Tumor necrosis factor inhibitor-induced serositis.

Abstract
A 46-year-old man with a history of asthma and psoriatic arthritis on adalimumab presented with fever, tachycardia, and hypoxia. He was diagnosed with pleural effusion and started on antibiotics, as it was noted to be an exudative effusion. Patient failed to improve on multiple courses of antibiotics, and his blood and pleural fluid cultures were negative. He was then started on prednisone 1 mg/kg and showed remarkable recovery. He was diagnosed with adalimumab-induced serositis.
AuthorsNarender Annapureddy, Shiv Kumar Agarwal, Natraj Ammakkanavar, Vijay Kanakadandi, Manpreet S Sabharwal, Hari Priya Sanjani, Priya Simoes, Girish N Nadkarni
JournalAmerican journal of therapeutics (Am J Ther) 2014 Sep-Oct Vol. 21 Issue 5 Pg. e166-8 ISSN: 1536-3686 [Electronic] United States
PMID23344110 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal, Humanized
  • Tumor Necrosis Factor-alpha
  • Adalimumab
Topics
  • Adalimumab
  • Antibodies, Monoclonal, Humanized (adverse effects)
  • Arthritis, Psoriatic (drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Serositis (chemically induced)
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)

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