HIV-related CD8+ cutaneous pseudolymphoma: efficacy of methotrexate.

Human immunodeficiency virus (HIV)-related CD8+ cutaneous pseudolymphoma (CD8+ cytotoxic T cell skin infiltrative disease) is an inflammatory process resulting from a massive infiltration of the skin by activated, oligoclonal, HIV-specific, cytotoxic T lymphocytes. Usually, CD8+ cutaneous pseudolymphoma affects patients with a deep immunosuppression, and is rare in patients with mild immunosuppression. In deeply immunocompromised patients, highly active antiretroviral therapy (HAART) is considered as the first-line treatment. In contrast, the choice of therapy in moderately immunocompromised patients and/or patients already receiving HAART remains nonconsensual. We report a case of HIV-related CD8+ cutaneous pseudolymphoma in a moderately immunocompromised patient who was successfully and safely treated with methotrexate. We review the literature on HIV-related CD8+ pseudolymphoma and the use of methotrexate in HIV-positive patients.
AuthorsS Ingen-Housz-Oro, E Sbidian, N Ortonne, D Penso-Assathiany, V Chambrin, M Bagot, H Bachelez, P Wolkenstein, O Chosidow
JournalDermatology (Basel, Switzerland) (Dermatology) Vol. 226 Issue 1 Pg. 15-8 ( 2013) ISSN: 1421-9832 [Electronic] Switzerland
PMID23343593 (Publication Type: Case Reports, Journal Article, Review)
CopyrightCopyright © 2013 S. Karger AG, Basel.
Chemical References
  • Dermatologic Agents
  • Methotrexate
  • Antiretroviral Therapy, Highly Active (methods)
  • CD8-Positive T-Lymphocytes (drug effects)
  • Dermatologic Agents (therapeutic use)
  • HIV Infections (drug therapy, immunology)
  • Humans
  • Immunocompromised Host
  • Male
  • Methotrexate (therapeutic use)
  • Middle Aged
  • Pseudolymphoma (drug therapy, immunology)
  • Skin Diseases (drug therapy, immunology)
  • Treatment Outcome

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