[In vitro accumulation of the photosensitizer Photosens in the atherosclerotic plaque of the human carotid artery].

Abstract

The investigation was undertaken to study the accumulation of the photosensitizer Photosens in arterial atherosclerotic plaques and to immunohistochemically identify cellular elements in them. Specimens were obtained during carotid endarterectomy. The preferential accumulation of Photosens occurred in the plaque areas containing the largest number of cells, such as macrophages and lymphocytes. The photosensitizer accumulated to a greater extent in the unstable plaques than in the stable ones, which seems to be associated with the more marked infiltration of unstable plaques by the cells involved in the inflammatory reaction.

• Authors: Iu E Efremova, E P Andreeva, G N Soboleva, N V Radiukhina, D F Beloiartsev, Iu A Karpov, E M Tararak
• Journal: Arkhiv patologii (Arkh Patol) 2012 Sep-Oct Vol. 74 Issue 5 Pg. 18-22 ISSN: 0004-1955 [Print] Russia (Federation)
• PMID: 23342654 (Publication Type: English Abstract, Journal Article)

Chemical References

• Photosensitizing Agents

Topics

• Carotid Arteries (metabolism, pathology)
• Carotid Stenosis (metabolism, pathology)
• Endarterectomy, Carotid
• Humans
• In Vitro Techniques
• Inflammation (metabolism)
• Lymphocytes (cytology, metabolism)
• Macrophages (cytology, metabolism)
• Photosensitizing Agents (analysis)
• Plaque, Atherosclerotic (metabolism, pathology)