Abstract |
A new type of cell growth inhibitory substance was isolated and purified from a powder of the root of Panax ginseng C.A. Meyer, which has been commonly used for the treatment of various disease as a commercial medical drug by the name of Korean Red Ginseng Powder. Data from the infrared spectra, proton and carbon-13 nuclear magnetic resonance, and high resolution mass spectra were identical with those of authentic panaxytriol. Cell growth inhibition by panaxytriol seemed to be tumor-specific. Its action was supposed to be more dose-dependent than time-dependent. In vivo antitumor efficacy of panaxytriol was tested against C57BL/6 mice transplanted with B 16 melanomas. Panaxytriol (40 mg/kg) administered intramuscularly produced significant tumor growth delays in mice (p less than 0.01).
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Authors | M Katano, H Yamamoto, H Matsunaga, M Mori, K Takata, M Nakamura |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 17
Issue 5
Pg. 1045-9
(May 1990)
ISSN: 0385-0684 [Print] Japan |
PMID | 2334170
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Alkynes
- Enediynes
- Fatty Alcohols
- Growth Inhibitors
- panaxytriol
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Topics |
- Alkynes
- Animals
- Cell Division
(drug effects)
- Enediynes
- Fatty Alcohols
(isolation & purification, pharmacology)
- Growth Inhibitors
- Humans
- Melanoma, Experimental
(pathology)
- Mice
- Neoplasm Transplantation
- Panax
(analysis)
- Plants, Medicinal
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