Abstract | BACKGROUND: METHODS: One-hundred ninety-five predialysis CKD patients were enrolled in this cross-sectional study. CAAC was assessed using multidetector computed tomography, and the prevalence of CAAC was examined. Intact FGF23 was measured in each patient. The risk factors for CAAC were evaluated using a logistic regression model. RESULTS: We found CAAC in 66% of the patients. The prevalence of CAAC significantly increased across CKD stages: it was 37% in CKD stages 1-2, 58% in stage 3; 75% in stage 4, and 77% in stage 5 (p < 0.01). In multivariate analysis, smoking, diabetes mellitus and log FGF23 were each identified as risk factors for CAAC. The study population was divided in quartiles of FGF23 levels. Compared with the lowest FGF23 quartile, each subsequent quartile had a progressively higher odds ratio (OR) for CAAC, adjusted for confounders ( ORs [95% confidence interval] of 2.34 [0.78 to 7.31], 5.28 [1.56 to 19.5], and 13.6 [2.92 to 74.6] for the second, third, and fourth quartiles, respectively. CONCLUSIONS: The prevalence of CAAC is increased with the decline in the kidney function. FGF23 is independently related to CAAC in patients with CKD who are not on dialysis.
|
Authors | Masaru Nakayama, Yoshiki Kaizu, Masaharu Nagata, Yoriko Ura, Hirofumi Ikeda, Sho Shimamoto, Kazuyoshi Kuma |
Journal | BMC nephrology
(BMC Nephrol)
Vol. 14
Pg. 22
(Jan 22 2013)
ISSN: 1471-2369 [Electronic] England |
PMID | 23339433
(Publication Type: Journal Article)
|
Chemical References |
- FGF23 protein, human
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
|
Topics |
- Aged
- Calcinosis
(blood, diagnosis, epidemiology)
- Carotid Artery Diseases
(blood, diagnosis, epidemiology)
- Comorbidity
- Dialysis
(statistics & numerical data)
- Female
- Fibroblast Growth Factor-23
- Fibroblast Growth Factors
(blood)
- Humans
- Japan
(epidemiology)
- Male
- Middle Aged
- Prevalence
- Renal Insufficiency, Chronic
(blood, diagnosis, rehabilitation)
- Risk Assessment
|