The effect of BLyS on the activity of peripheral B lymphocytes mediated by BLyS receptors in patients with systemic lupus erythematosus.

Abstract

The study was promoted to probe into the effect of BLyS on the activity of peripheral B lymphocytes mediated by BLyS receptors in patients with systemic lupus erythematosus (SLE). Thirty new-onset patients having fulfilled the American College of Rheumatology (ACR) revised criteria for the diagnosis of SLE. Twenty age-matched healthy volunteers were recruited for this study. Peripheral blood samples were used to analyze the expression of BLyS protein and related receptors (BR3, TACI), to detect peripheral B cell subpopulations of different phases. Clinical disease activity was evaluated according to the systemic lupus erythematosus disease activity index (SLEDAI-2000). The percentage of CD19(+)CD5(+), CD19(+)CD27(+), CD19(+)CD38(+) and total CD19(+) in the peripheral blood is significantly higher in SLE patients than that in healthy controls (p < 0.01). BLyS concentrations and TACI expression are up-regulated in SLE patients (p < 0.01) while BR3 showed no differences between the two groups (p > 0.05). BLyS concentrations and TACI MFI both showed positive correlation with SLEDAI (r(2) = 0.391, p < 0.001, r(2) = 0.339, p = 0.001), whereas BR3 expression showed no relationship with SLEDAI. The disorders of peripheral B cell subsets maybe reflect the effect of BLyS on the activity of peripheral B lymphocytes mediated by BLyS receptors. The significant up-regulation of BLyS and its receptors, especially TACI may serve as a target for the treatment of SLE.

• Authors: Yan Cheng, Shangxue Yan, Wei Zhao, Qiong Huang, Li Lian, Wei Wei
• Journal: Scandinavian journal of clinical and laboratory investigation (Scand J Clin Lab Invest) Vol. 73 Issue 2 Pg. 141-7 (Mar 2013) ISSN: 1502-7686 [Electronic] England
• PMID: 23336587 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• B-Cell Activating Factor
• B-Cell Activation Factor Receptor
• TNFRSF13B protein, human
• TNFSF13B protein, human
• Transmembrane Activator and CAML Interactor Protein

Topics

• Adolescent
• Adult
• Aged
• B-Cell Activating Factor (blood, physiology)
• B-Cell Activation Factor Receptor (metabolism)
• B-Lymphocytes (metabolism)
• Case-Control Studies
• Female
• Humans
• Lupus Erythematosus, Systemic (immunology, metabolism, pathology)
• Male
• Middle Aged
• Transmembrane Activator and CAML Interactor Protein (metabolism)
• Young Adult