Abstract | AIM: METHODS:
DNA samples were isolated from 300 patients with MNG and 142 controls. Polymerase chain reaction-restriction fragment length polymorphism and agarose gel electrophoresis were used. RESULTS: The D727E polymorphism G-allele frequency and the CG and GG genotypes were significantly higher in patients with MNG. However, there was no significant difference in the P52T polymorphism between patients and control subjects. CONCLUSIONS: As a conclusion, the D727E polymorphism G allele may be related to MNG development in the studied population.
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Authors | Banu Bayram, Resit Sonmez, Sedat Bozari, Harun Onlu, Züleyha Turkoglu, Fezan Sahin Mutlu |
Journal | Genetic testing and molecular biomarkers
(Genet Test Mol Biomarkers)
Vol. 17
Issue 2
Pg. 109-14
(Feb 2013)
ISSN: 1945-0257 [Electronic] United States |
PMID | 23336574
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Alleles
- Disease Progression
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Goiter, Nodular
(genetics, physiopathology)
- Humans
- Male
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Receptors, Thyrotropin
(genetics)
- Turkey
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