Ospemifene, vulvovaginal atrophy, and breast cancer.

Abstract

The incidence and severity of vulvovaginal atrophy (VVA) in postmenopausal breast cancer patients has a significant impact on quality of life. While the etiology of VVA is primarily related to low estrogen levels seen in menopause, women with breast cancer have an added risk of VVA induced by a combination of chemotherapy, hormonal therapy, and menopause. Ospemifene is a new, non-hormonal selective estrogen receptor modulator (SERM) triphenylethylene derivative that is effective in treating VVA in postmenopausal women. Although other SERMs have antagonistic effects on the vagina, ospemifene exerts an estrogen-like effect on the vaginal epithelium. This review will focus on data demonstrating the antiestrogenic activity of ospemifene in several unique breast cancer animal models, and the implications for utilizing ospemifene in patients with breast cancer suffering from VVA. Additional research addressing the expanded use of ospemifene in breast cancer patients is also warranted.

• Authors: Gregory T Wurz, Lin H Soe, Michael W DeGregorio
• Journal: Maturitas (Maturitas) Vol. 74 Issue 3 Pg. 220-5 (Mar 2013) ISSN: 1873-4111 [Electronic] Ireland
• PMID: 23332519 (Publication Type: Journal Article, Review)
• Copyright: Published by Elsevier Ireland Ltd.

Chemical References

• Antineoplastic Agents, Hormonal
• Selective Estrogen Receptor Modulators
• Tamoxifen
• Ospemifene

Topics

• Animals
• Antineoplastic Agents, Hormonal (therapeutic use)
• Atrophy
• Breast Neoplasms (drug therapy)
• Disease Models, Animal
• Female
• Humans
• Menopause (physiology)
• Postmenopause (physiology)
• Quality of Life
• Selective Estrogen Receptor Modulators (therapeutic use)
• Tamoxifen (analogs & derivatives, therapeutic use)
• Vagina (drug effects, pathology)
• Vulva (drug effects, pathology)