Abstract | AIM: To investigate whether the apoptotic cascade is activated through the extrinsic pathway in epithelial lining and connective tissue of radicular cysts. METHODOLOGY: RESULTS: The three antibodies were detected in connective tissue fibroblasts of all radicular cysts; TRAIL and DR5 immunoexpression was significantly greater (P < 0.05) compared with that of caspase-3. The three antibodies were also expressed in almost all epithelial layers and in endothelial cells of newly formed vessels. CONCLUSION: The involvement of apoptosis in the pathogenesis of radicular cysts, demonstrated by the immunoexpression patterns of TRAIL, DR5 and caspase-3 in lining epithelium and connective tissue, may explain their bland clinical aggressiveness and slow, benign evolution.
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Authors | C Loreto, C Galanti, R Leonardi, G Musumeci, G Pannone, G Palazzo, M C Rusu |
Journal | International endodontic journal
(Int Endod J)
Vol. 46
Issue 7
Pg. 642-8
(Jul 2013)
ISSN: 1365-2591 [Electronic] England |
PMID | 23331055
(Publication Type: Journal Article)
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Copyright | © 2012 International Endodontic Journal. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antigen-Antibody Complex
- Coloring Agents
- Receptors, TNF-Related Apoptosis-Inducing Ligand
- TNF-Related Apoptosis-Inducing Ligand
- TNFSF10 protein, human
- 3,3'-Diaminobenzidine
- Caspase 3
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Topics |
- 3,3'-Diaminobenzidine
- Antigen-Antibody Complex
- Apoptosis
(physiology)
- Caspase 3
(analysis)
- Cell Count
- Coloring Agents
- Connective Tissue
(pathology)
- Connective Tissue Cells
(pathology)
- Endothelial Cells
(pathology)
- Endothelium, Vascular
(pathology)
- Epithelial Cells
(pathology)
- Female
- Fibroblasts
(pathology)
- Humans
- Immunohistochemistry
- Male
- Radicular Cyst
(etiology, pathology)
- Receptors, TNF-Related Apoptosis-Inducing Ligand
(analysis)
- TNF-Related Apoptosis-Inducing Ligand
(analysis)
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