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Cardioprotective properties of dimethyl sulfoxide during global ischemia-reperfusion of isolated rat heart.

Abstract
Cardioprotective properties of dimethyl sulfoxide (DMSO) were studied in the isolated rat heart model. Intraperitoneal administration of DMSO to animals for 3 days before the experiment, but not addition of DMSO to the perfusate, reduced infarction size. Both intraperitoneal and intracoronary administration of DMSO reduced the severity of postischemic left-ventricular dysfunction.
AuthorsYu V Dmitriev, S M Minasian, E A Demchenko, M M Galagudza
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 154 Issue 1 Pg. 47-50 (Nov 2012) ISSN: 1573-8221 [Electronic] United States
PMID23330088 (Publication Type: Journal Article)
Chemical References
  • Cardiotonic Agents
  • Dimethyl Sulfoxide
Topics
  • Animals
  • Cardiotonic Agents (pharmacology)
  • Dimethyl Sulfoxide (pharmacology)
  • Heart (physiopathology)
  • Heart Ventricles (drug effects)
  • Male
  • Myocardial Contraction
  • Myocardial Infarction (drug therapy)
  • Myocardial Reperfusion Injury (drug therapy, physiopathology, prevention & control)
  • Rats
  • Rats, Wistar
  • Ventricular Dysfunction, Left (drug therapy)
  • Ventricular Function, Left (drug effects)

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