Abstract |
Cardioprotective properties of dimethyl sulfoxide ( DMSO) were studied in the isolated rat heart model. Intraperitoneal administration of DMSO to animals for 3 days before the experiment, but not addition of DMSO to the perfusate, reduced infarction size. Both intraperitoneal and intracoronary administration of DMSO reduced the severity of postischemic left-ventricular dysfunction.
|
Authors | Yu V Dmitriev, S M Minasian, E A Demchenko, M M Galagudza |
Journal | Bulletin of experimental biology and medicine
(Bull Exp Biol Med)
Vol. 154
Issue 1
Pg. 47-50
(Nov 2012)
ISSN: 1573-8221 [Electronic] United States |
PMID | 23330088
(Publication Type: Journal Article)
|
Chemical References |
- Cardiotonic Agents
- Dimethyl Sulfoxide
|
Topics |
- Animals
- Cardiotonic Agents
(pharmacology)
- Dimethyl Sulfoxide
(pharmacology)
- Heart
(physiopathology)
- Heart Ventricles
(drug effects)
- Male
- Myocardial Contraction
- Myocardial Infarction
(drug therapy)
- Myocardial Reperfusion Injury
(drug therapy, physiopathology, prevention & control)
- Rats
- Rats, Wistar
- Ventricular Dysfunction, Left
(drug therapy)
- Ventricular Function, Left
(drug effects)
|