The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism.

Abstract

OBJECTIVE:

To study the treatment effect and safety of diazoxide on patients with congenital hyperinsulinism (CHI).

RESEARCH DESIGN AND METHODS:

A total of 44 patients who have been hospitalized to our hospital and used diazoxide as a trial after diagnosis of CHI were chosen as research subjects. The clinical data of the patients were analyzed, and the treatment effects and safety of diazoxide on CHI were evaluated.

RESULTS:

In the 44 patients studied, the blood glucoses of 36 cases recovered to normal level after using diazoxide, indicating that the 36 patients respond to the treatment of diazoxide. Eight cases still showed severe hypoglycemia after using diazoxide for 10 days, which indicated that the eight patients were unresponsive to diazoxide treatment. Eighteen patients suffered the side effect of fluid retention, and 12 patients suffered transient gastrointestinal reactions.

CONCLUSION:

Diazoxide is a first-line treatment of CHI with high safety. Most of the patients with CHI were responsive to diazoxide treatment. Diazoxide should be used as a trial immediately after CHI diagnosis was made.

• Authors: Shuwen Hu, Zidi Xu, Jie Yan, Min Liu, Bing Sun, Wenjing Li, Yanmei Sang
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 25 Issue 11-12 Pg. 1119-22 ( 2012) ISSN: 0334-018X [Print] Germany
• PMID: 23329758 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Blood Glucose
• Diazoxide

Topics

• Age of Onset
• Antihypertensive Agents (adverse effects, therapeutic use)
• Blood Glucose (analysis)
• China (epidemiology)
• Congenital Hyperinsulinism (blood, diagnosis, drug therapy, epidemiology)
• Diazoxide (adverse effects, therapeutic use)
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Treatment Outcome