Surfactant protein-A concentration in sera from dogs with pulmonary parenchymal diseases.

Abstract

Pulmonary surfactant protein A (SP-A) is used as a biomarker to understand the clinical features of pulmonary diseases and associated prognostic indices in human medicine. This study was conducted to investigate whether or not serum SP-A concentration can be used as a biomarker for identifying pulmonary parenchymal diseases in dogs. Thirty-two dogs with pulmonary parenchymal diseases, 34 with nonrespiratory diseases and 57 healthy dogs were included. Serum SP-A concentration was measured in all dogs using sandwich enzyme linked immunosorbent assay with an anti-dog SP-A polyclonal antibody. Median serum SP-A concentration in healthy dogs was <2.0 ng/ml, whereas that in dogs with aspiration pneumonia (n=11), primary lung tumors (n=9) and blunt traumatic lung injury (BTLI; n=12) was 3.1, 7.2 and 2.6 ng/ml, respectively; these values were significantly higher than those in healthy dogs. The serum SP-A concentration in dogs with nonrespiratory diseases was comparable with that in healthy dogs. No correlation was observed between the serum SP-A and plasma C-reactive protein concentrations in dogs with aspiration pneumonia and BTLI. There was a significant correlation between the serum SP-A concentration and thoracic radiographic changes in dogs with BTLI. These findings suggest that the serum SP-A concentration may be a useful clinical biomarker of alveolar damage that can be used for differential diagnosis of pulmonary parenchymal diseases and nonrespiratory diseases in dogs.

• Authors: Katsuhito Sone, Hideo Akiyoshi, Junichiro Shimizu, Zheng Cao, Yijyun Li, Toshiyuki Tanaka, Akiyoshi Hayashi, Shunji Sugii, Fumihito Ohashi
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 75 Issue 6 Pg. 685-91 ( 2013) ISSN: 1347-7439 [Electronic] Japan
• PMID: 23328605 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Pulmonary Surfactant-Associated Protein A

Topics

• Animals
• Biomarkers (blood)
• Case-Control Studies
• Dog Diseases (blood, metabolism)
• Dogs
• Enzyme-Linked Immunosorbent Assay (veterinary)
• Female
• Lung Diseases (blood, metabolism, veterinary)
• Male
• Pulmonary Surfactant-Associated Protein A (blood, metabolism)