Abstract | BACKGROUND:
Hypoglycemic risk and improved glycemic control have to be weightened when a decision on intensification of treatment of type 2 diabetes mellitus with basal insulin is made. Findings from randomized studies are available in this respect, and should be complemented by data from routine treatment. METHODS: RESULTS: In Germany, 2,090 patients were eligible for the full analysis set and 1,671 patients for the effectiveness analysis set. The mean age was 64.9 years, mean duration of diabetes 9.36 years, and mean duration of OAD treatment 7.29 years. Three patients (0.14%) experienced a SADR (1 fall resulting in death, 2 major hypoglycemic events). At the final visit, there was a significant reduction in major hypoglycemic events if compared with the period before starting insulin treatment (0.002 versus 0.120 events per patient year, p < 0.001), as were minor hypoglycemic events (0.880 versus 1.588 events per patient year, p = 0.006). The mean body weight and BMI decreased by -0.9 kg (p < 0.001) and-0.35 kg/m2 (p < 0.001) respectively and the mean HbA(1c) level improved from 8.45 +/- 1.19% to 7.30 +/- 0.92% (-1.15 +/- 1.08%; p < 0.001). The mean fasting plasma glucose level and plasma glucose variability were significantly reduced. CONCLUSION:
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Authors | A Liebl, B Wilhelm, M Kaiser |
Journal | MMW Fortschritte der Medizin
(MMW Fortschr Med)
Vol. 154 Suppl 4
Pg. 102-9
(Dec 17 2012)
ISSN: 1438-3276 [Print] Germany |
Vernacular Title | Einmal täglich Insulin detemir bei Patienten mitTyp-2-Diabetes. Ergebnisse deutscher Zentren aus einer 6-monatigen internationalen Beobachtungsstudie (SOLVE). |
PMID | 23326928
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin, Long-Acting
- hemoglobin A1c protein, human
- Insulin Detemir
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Glycated Hemoglobin
(metabolism)
- Humans
- Hypoglycemia
(blood, chemically induced)
- Hypoglycemic Agents
(administration & dosage, adverse effects)
- Insulin Detemir
- Insulin, Long-Acting
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Prospective Studies
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