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The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels.

Abstract
The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC) and show that CD133 interacts with plakoglobin (also known as γ-catenin), a desmosomal linker protein. We further demonstrate that knockdown of CD133 by RNA interference (RNAi) results in the downregulation of desmoglein-2, a desmosomal cadherin, and abrogates cell-cell adhesion and tumorigenicity of CCC stem cells. We speculate that CD133 may be a promising target for cancer chemotherapy.
AuthorsRyo Koyama-Nasu, Rina Takahashi, Satoshi Yanagida, Yukiko Nasu-Nishimura, Masaaki Oyama, Hiroko Kozuka-Hata, Ryo Haruta, Emi Manabe, Akemi Hoshino-Okubo, Hiroko Omi, Nozomu Yanaihara, Aikou Okamoto, Tadao Tanaka, Tetsu Akiyama
JournalPloS one (PLoS One) Vol. 8 Issue 1 Pg. e53710 ( 2013) ISSN: 1932-6203 [Electronic] United States
PMID23326490 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • AC133 Antigen
  • Antigens, CD
  • Biomarkers, Tumor
  • DSG2 protein, human
  • Desmoglein 2
  • Glycoproteins
  • PROM1 protein, human
  • Peptides
  • Prom1 protein, mouse
  • gamma Catenin
Topics
  • AC133 Antigen
  • Animals
  • Antigens, CD (metabolism)
  • Biomarkers, Tumor (metabolism)
  • Caco-2 Cells
  • Cell Adhesion
  • Cell Transformation, Neoplastic (metabolism, pathology)
  • Desmoglein 2 (metabolism)
  • Glycoproteins (metabolism)
  • Humans
  • Mice
  • Neoplastic Stem Cells (metabolism, pathology)
  • Peptides (metabolism)
  • Protein Binding
  • gamma Catenin (metabolism)

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