Abstract |
Gastrointestinal symptoms are common in patients with common variable immunodeficiency disorders (CVID) and less frequent in X-linked agammaglobulinemia (XLA) although the exact prevalence is not well established. In this study, endoscopic screening was performed in 30 patients with CVID and four patients with XLA. Endoscopic and/or histological abnormalities were detected in 25 of 30 patients with CVID (83 %), regardless of symptoms, and in nine of these patients the results prompted medical treatment. Helicobacter pylori-associated gastritis, adenomatous polyps, and lymphoid hyperplasia were most frequently encountered; no malignancies were detected. Adenomatous polyps were found in two of the four patients with XLA at a relative young age. In conclusion, gastrointestinal pathology is frequent in patients with CVID regardless of symptoms. Patients with XLA seem to be at risk for colorectal adenomas at a young age.
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Authors | L J Maarschalk-Ellerbroek, B Oldenburg, I M H Mombers, A I M Hoepelman, L A A Brosens, G J A Offerhaus, P M Ellerbroek |
Journal | Endoscopy
(Endoscopy)
Vol. 45
Issue 4
Pg. 320-3
( 2013)
ISSN: 1438-8812 [Electronic] Germany |
PMID | 23325698
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Georg Thieme Verlag KG Stuttgart · New York. |
Topics |
- Adenomatous Polyps
(complications, diagnosis)
- Adolescent
- Adult
- Agammaglobulinemia
(complications)
- Aged
- Colonoscopy
- Colorectal Neoplasms
(complications, diagnosis)
- Common Variable Immunodeficiency
(complications)
- Cross-Sectional Studies
- Female
- Gastritis
(complications, diagnosis, microbiology)
- Gastroscopy
- Genetic Diseases, X-Linked
(complications)
- Helicobacter Infections
(diagnosis)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Population Surveillance
- Pseudolymphoma
(complications, diagnosis)
- Young Adult
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