HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Salmonella polarises peptide-MHC-II presentation towards an unconventional Type B CD4+ T-cell response.

Abstract
Distinct peptide-MHC-II complexes, recognised by Type A and B CD4(+) T-cell subsets, are generated when antigen is loaded in different intracellular compartments. Conventional Type A T cells recognize their peptide epitope regardless of the route of processing, whereas unconventional Type B T cells only recognise exogenously supplied peptide. Type B T cells are implicated in autoimmune conditions and may break tolerance by escaping negative selection. Here we show that Salmonella differentially influences presentation of antigen to Type A and B T cells. Infection of bone marrow-derived dendritic cells (BMDCs) with Salmonella enterica serovar Typhimurium (S. Typhimurium) reduced presentation of antigen to Type A T cells but enhanced presentation of exogenous peptide to Type B T cells. Exposure to S. Typhimurium was sufficient to enhance Type B T-cell activation. Salmonella Typhimurium infection reduced surface expression of MHC-II, by an invariant chain-independent trafficking mechanism, resulting in accumulation of MHC-II in multi-vesicular bodies. Reduced MHC-II surface expression in S. Typhimurium-infected BMDCs correlated with reduced antigen presentation to Type A T cells. Salmonella infection is implicated in reactive arthritis. Therefore, polarisation of antigen presentation towards a Type B response by Salmonella may be a predisposing factor in autoimmune conditions such as reactive arthritis.
AuthorsNicola P Jackson, Yu Hui Kang, Nicolas Lapaque, Hans Janssen, John Trowsdale, Adrian P Kelly
JournalEuropean journal of immunology (Eur J Immunol) Vol. 43 Issue 4 Pg. 897-906 (Apr 2013) ISSN: 1521-4141 [Electronic] Germany
PMID23319341 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemical References
  • Antigens, Bacterial
  • Antigens, Differentiation, B-Lymphocyte
  • Clathrin
  • Histocompatibility Antigens Class II
  • Peptides
  • invariant chain
Topics
  • Antigen Presentation (immunology)
  • Antigens, Bacterial (chemistry, immunology)
  • Antigens, Differentiation, B-Lymphocyte (metabolism)
  • CD4-Positive T-Lymphocytes (immunology)
  • Cell Line
  • Cells, Cultured
  • Clathrin (metabolism)
  • Histocompatibility Antigens Class II (immunology, metabolism)
  • Humans
  • Multivesicular Bodies (metabolism)
  • Peptides (immunology, metabolism)
  • Protein Transport
  • Salmonella (immunology)
  • Salmonella Infections (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: