TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).

Abstract

The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor -induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21(WAF1/CIP1). Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.

• Authors: Y Liu, R Raheja, N Yeh, D Ciznadija, A M Pedraza, T Ozawa, E Hukkelhoven, H Erdjument-Bromage, P Tempst, N P Gauthier, C Brennan, E C Holland, A Koff
• Journal: Oncogene (Oncogene) Vol. 33 Issue 3 Pg. 308-15 (Jan 16 2014) ISSN: 1476-5594 [Electronic] England
• PMID: 23318451 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Carrier Proteins
• Cyclin-Dependent Kinase Inhibitor p21
• RNA, Messenger
• TRIM3 protein, human
• TRIM3 protein, mouse
• Tumor Suppressor Proteins

Topics

• Animals
• Carrier Proteins (genetics, metabolism)
• Cell Line
• Cell Line, Transformed
• Cell Line, Tumor
• Cyclin-Dependent Kinase Inhibitor p21 (genetics, metabolism)
• Gene Expression Regulation, Neoplastic
• Glioblastoma (genetics, metabolism, pathology)
• Humans
• Immunoblotting
• Loss of Heterozygosity
• Mice
• Mice, Knockout
• Mutation
• Protein Binding
• RNA Interference
• RNA, Messenger (genetics, metabolism)
• Tumor Suppressor Proteins (genetics, metabolism)