Abstract | AIM: Whether hepatic function can recover in cirrhotic patients after splenectomy remains controversial. METHODS: All consecutive Japanese patients with hepatic cirrhosis due to hepatitis C who had undergone elective splenectomy in Kyushu University Hospital between January 2008 and December 2009 were included in this retrospective study. Prothrombin time, serum albumin and total bilirubin concentrations were reviewed before and after splenectomy and analyzed to clarify whether splenectomy improves hepatic function in patients with cirrhosis and to determine the factors predictive of improvement in hepatic function. RESULTS: Prothrombin time and total serum bilirubin concentration improved after splenectomy; however, serum albumin concentrations did not increase significantly. Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3 mg/dL in 52.3% of patients and prothrombin time had improved by over 10% in 52.3% of patients. Multiple linear regression analysis identified hepatic vein waveform (HVWF) type I (P = 0.0174) and spleen weight (P = 0.0394) as independent predictors of improvement in prothrombin time and preoperative total serum bilirubin (P = 0.0002) as the only independent predictor of decrease in total bilirubin. Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they were not improved in patients with HVWF type II. CONCLUSION:
|
Authors | Nao Kinjo, Yoshihiro Nagao, Tomohiko Akahoshi, Kamori Masahiro, Naotaka Hashimoto, Hideo Uehara, Hirohumi Kawanaka, Morimasa Tomikawa, Ken Shirabe, Makoto Hashizume, Yoshihiko Maehara |
Journal | Hepatology research : the official journal of the Japan Society of Hepatology
(Hepatol Res)
Vol. 43
Issue 9
Pg. 933-41
(Sep 2013)
ISSN: 1386-6346 [Print] Netherlands |
PMID | 23317427
(Publication Type: Journal Article)
|
Copyright | © 2012 The Japan Society of Hepatology. |