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Quantitative real-time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA expression in breast cancer.

Abstract
Breast cancer is the leading cause of cancer deaths among women worldwide, including Thailand. In the present study, the differential mRNA expression of SVEP1, LPHN3, KLB, ITGA7, SEMA3G, TNS1 and MMP13 genes was examined in breast cancer using quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR). Among these genes, increased LPHN3 and MMP13 mRNA expression levels correlated with axillary-node metastasis (P=0.02). Multiple logistic regression analysis revealed that LPHN3 and MMP13 mRNA expression is significantly associated with axillary node status in breast cancer (P=0.04).
AuthorsManas Kotepui, Charin Thawornkuno, Porntip Chavalitshewinkoon-Petmitr, Phaibul Punyarit, Songsak Petmitr
JournalAsian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 11 Pg. 5879-82 ( 2012) ISSN: 2476-762X [Electronic] Thailand
PMID23317273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • ADGRL3 protein, human
  • Antigens, CD
  • Biomarkers, Tumor
  • Cell Adhesion Molecules
  • Integrin alpha Chains
  • Microfilament Proteins
  • RNA, Messenger
  • Receptors, G-Protein-Coupled
  • Receptors, Peptide
  • SVEP1 protein, human
  • Semaphorins
  • TNS1 protein, human
  • Tensins
  • integrin alpha7
  • semaphorin 3G, human
  • MMP13 protein, human
  • Matrix Metalloproteinase 13
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD (genetics)
  • Axilla
  • Biomarkers, Tumor (genetics)
  • Breast Neoplasms (genetics, pathology)
  • Cell Adhesion Molecules (genetics)
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Integrin alpha Chains (genetics)
  • Lymphatic Metastasis
  • Matrix Metalloproteinase 13 (genetics)
  • Microfilament Proteins (genetics)
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • RNA, Messenger (genetics)
  • Real-Time Polymerase Chain Reaction
  • Receptors, G-Protein-Coupled (genetics)
  • Receptors, Peptide (genetics)
  • Retrospective Studies
  • Reverse Transcriptase Polymerase Chain Reaction
  • Semaphorins (genetics)
  • Tensins
  • Thailand

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