Abstract | BACKGROUND: MATERIALS AND METHODS: Data regarding general characteristics and smoking status was collected using a self-administered smoking questionnaire. The Fagerstrom test for nicotine dependence (FTND) was used to determine nicotine dependence of the participants, and a total of 381 participants were classified into 3 groups of nicotine dependence: low (n=205, 53.8%), moderate (n=127, 33.3%), and high dependence groups (n=49, 12.9%). Stepwise multiple linear regression model and receiver operating characteristic (ROC) curves analyses were used to determine the validity of urinary cotinine for high nicotine dependence. RESULTS: In correlation analysis, urinary cotinine levels increased with FTND score (r=0.567, P<0.001). ROC curves analysis showed that urinary cotinine levels predicted the high-dependence group with reasonable accuracy (optimal cut-off value=1,000 ng/mL; AUC=0.82; P<0.001; sensitivity=71.4%; specificity=74.4%). In stepwise multiple regression analysis, the total smoking period (β=0.042, P=0.001) and urinary cotinine levels (β=0.234, P<0.001) were positively associated with nicotine dependence, whereas an inverse association was observed between highest education levels (>16 years) and nicotine dependence (β=-0.573, P=0.034). CONCLUSIONS: The results of this study support the validity of using urinary cotinine levels for assessment of nicotine dependence in active smokers.
|
Authors | Hyun-Suk Jung, Yeol Kim, Jungsik Son, Young-Jee Jeon, Hong-Gwan Seo, So-Hee Park, Bong Ryul Huh |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 13
Issue 11
Pg. 5483-8
( 2012)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 23317204
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Adolescent
- Adult
- Area Under Curve
- Biomarkers
(urine)
- Cotinine
(urine)
- Female
- Humans
- Male
- Middle Aged
- Republic of Korea
(epidemiology)
- Smoking
(urine)
- Surveys and Questionnaires
- Tobacco Use Disorder
(diagnosis, epidemiology, urine)
- Young Adult
|