Abstract | INTRODUCTION: The major drawbacks associated with most of the anti- cancer drugs are their potential adverse effects. Distribution of these drugs throughout the body causes untoward adverse effects and less accumulation of drug at the site of tumors also causes decrease in therapeutic efficacy. Targeted nanomedicines are the emerging systems to improve the targetability of drug to the tumor site and to reduce the toxicity with maximum efficacy. Copolymers of poly-lactic acid (PLA) and D-α-tocopheryl polyethylene glycol 1000 succinate ( Vitamin-E TPGS or TPGS) are innovative materials being actively investigated for the fabrication of non-targeted and targeted nanomedicines for diagnosis and therapy of cancer. AREAS COVERED: EXPERT OPINION:
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Authors | Mahalingam R Vijayakumar, Madaswamy S Muthu, Sanjay Singh |
Journal | Expert opinion on drug delivery
(Expert Opin Drug Deliv)
Vol. 10
Issue 4
Pg. 529-43
(Apr 2013)
ISSN: 1744-7593 [Electronic] England |
PMID | 23316695
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Biocompatible Materials
- Lactates
- Polyesters
- Succinates
- poly(lactic acid-ethylene glycol)
- poly(lactide)-tocopheryl polyethylene glycol succinate
- Polyethylene Glycols
- poly(lactide)
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, chemistry)
- Biocompatible Materials
- Drug Delivery Systems
- Humans
- Lactates
(chemistry)
- Nanomedicine
- Nanoparticles
(chemistry)
- Neoplasms
(diagnosis, drug therapy)
- Polyesters
(chemistry)
- Polyethylene Glycols
(chemistry)
- Succinates
(chemistry)
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