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Orbital myeloid sarcoma in an adult with acute myeloid leukemia, FAB M1, and 12p-deletion.

Abstract
A 49-year-old woman with acute myeloid leukemia, FAB M1 subtype, and 12p deletion, presented with progressive right proptosis and diplopia for 1 week. Orbital CT revealed a homogenously enhancing, orbital mass engulfing the inferior rectus muscle. Histopathology revealed myeloid sarcoma for which she underwent external beam radiotherapy. Subsequently, there was no sign of local recurrence, but she succumbed to leukemia involving the central nervous system. This is the first case, to the authors' knowledge, of an orbital sarcoma of FAB M1 myeloblasts bearing a 12p deletion.
AuthorsPatricia A Ple-plakon, Hakan Demirci, Jason X Cheng, Victor M Elner
JournalOphthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2013 May-Jun Vol. 29 Issue 3 Pg. e73-5 ISSN: 1537-2677 [Electronic] United States
PMID23314098 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Neoplasm Proteins
  • Sialic Acid Binding Ig-like Lectin 3
Topics
  • Biomarkers, Tumor (metabolism)
  • Chromosome Deletion
  • Chromosomes, Human, Pair 12 (genetics)
  • Diplopia (diagnosis)
  • Exophthalmos (diagnosis)
  • Fatal Outcome
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Ki-67 Antigen (metabolism)
  • Leukemia, Myeloid, Acute (genetics, pathology, radiotherapy)
  • Middle Aged
  • Neoplasm Proteins (metabolism)
  • Neoplasms, Second Primary (pathology)
  • Orbital Neoplasms (diagnostic imaging, pathology, radiotherapy)
  • Sarcoma, Myeloid (diagnostic imaging, pathology, radiotherapy)
  • Sialic Acid Binding Ig-like Lectin 3 (metabolism)
  • Tomography, X-Ray Computed

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