Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng (family Araliaceae) is traditionally used as a remedy for cancer, inflammation, stress and aging. AIM OF STUDY: To explore whether ginsenosides Rg5 and Rh3, the main constituents of heat-processed ginseng (the root of Panax ginseng), could protect memory deficit. MATERIALS AND METHODS: We isolated ginsenosides Rh3 and Rg5 from heated-processed ginseng treated with and without human feces, respectively. Then we investigated their protective effects on memory impairment using the passive avoidance, Y-maze and Morris water maze tasks in mice. Memory deficit was induced in mice by the intraperitoneal injection of scopolamine. RESULTS: CONCLUSIONS:
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Authors | Eun-Jin Kim, Il-Hoon Jung, Thi Kim Van Le, Jin-Ju Jeong, Nam-Jae Kim, Dong-Hyun Kim |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 146
Issue 1
Pg. 294-9
(Mar 07 2013)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 23313392
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013. Published by Elsevier Ireland Ltd. |
Chemical References |
- Brain-Derived Neurotrophic Factor
- Creb1 protein, mouse
- Cyclic AMP Response Element-Binding Protein
- Ginsenosides
- Neuroprotective Agents
- ginsenoside Rg5
- ginsenoside Rh3
- Scopolamine
- Acetylcholinesterase
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Topics |
- Acetylcholinesterase
(metabolism)
- Animals
- Avoidance Learning
(drug effects)
- Brain-Derived Neurotrophic Factor
(metabolism)
- Cyclic AMP Response Element-Binding Protein
(metabolism)
- Ginsenosides
(pharmacology, therapeutic use)
- Male
- Maze Learning
(drug effects)
- Memory Disorders
(chemically induced, drug therapy, metabolism, physiopathology)
- Mice
- Mice, Inbred ICR
- Neuroprotective Agents
(pharmacology, therapeutic use)
- Scopolamine
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