Phytotherapeutic management of polycystic ovary syndrome: role of aerial parts of wood betony (Stachys lavandulifolia).

Abstract

Pharmacological treatments of polycystic ovary syndrome (PCOS) have side effects. We compared the efficacy and safety of the aerial parts of wood botany (AWB) with those of Medroxyprogesterone acetate (MPA) in the management of abnormal uterine bleeding (AUB) due to PCOS. We conducted a randomized clinical trial of 66 women aged 15-45 years, with AUB. Participants were randomly assigned to either cyclical 10-mg BD MPA for three cycles or 5 g ABW TDS for three months. Clinical symptoms and paraclinical parameters were recorded before and 3 months after initiation of the treatment. Comparisons were made using generalized linear models. Age-adjusted prevalence rate of different patterns of AUB, decreased from 2.7 (95%CIs: 0.6-48.0) to 1.1 (95%CIs: 0.1-18.3) for patients taking MPA, and from 2.5 (95% CIs: 0.2-40.2) to 0.7 (95%CIs: 0.0-12.1). Decrease in prevalence rate was similar across two arms of the study (P value = 0.248). Adverse effects were observed less frequently (24.2%) among participants on MPA than among those on AWB (45.5%). The multivariate-adjusted odds for developing adverse reaction of MPA was 0.40 (95%CIs: 0.14-1.19, P value = 0.099) time odds of AWB. In conclusion, AWB may be used as an alternative for MPA in the treatment of AUB caused by PCOS.

• Authors: Nasrin Jalilian, Masoud Modarresi, Mansour Rezaie, Leila Ghaderi, Mohammadreza Bozorgmanesh
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 27 Issue 11 Pg. 1708-13 (Nov 2013) ISSN: 1099-1573 [Electronic] England
• PMID: 23307315 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2013 John Wiley & Sons, Ltd.

Chemical References

• Medroxyprogesterone Acetate

Topics

• Adolescent
• Adult
• Female
• Humans
• Linear Models
• Medroxyprogesterone Acetate (therapeutic use)
• Phytotherapy
• Plant Components, Aerial (chemistry)
• Polycystic Ovary Syndrome (drug therapy)
• Stachys (chemistry)
• Uterine Hemorrhage (drug therapy)
• Young Adult