Full-mouth disinfection as a therapeutic protocol for type-2 diabetic subjects with chronic periodontitis: twelve-month clinical outcomes: a randomized controlled clinical trial.

Abstract

AIM:

The aim of this randomized controlled clinical trial was to evaluate the clinical effects of chlorhexidine (CHX) application in a full-mouth disinfection (FMD) protocol in poorly controlled type-2 diabetic subjects with generalized chronic periodontitis.

MATERIAL AND METHODS:

Thirty-eight subjects were randomly assigned into FMD group (n=19): full-mouth scaling and root planing (FMSRP) within 24 h + local application of CHX gel + CHX rinses for 60 days or Control group (n = 19): FMSRP within 24 h + local application of placebo gel + placebo rinses for 60 days. Clinical parameters, glycated haemoglobin and fasting plasma glucose were assessed at baseline, 3, 6 and 12 months post-therapies.

RESULTS:

All clinical parameters improved significantly at 3, 6 and 12 months post-therapies for both groups (p < 0.05). There were no significant differences between groups for any clinical parameters, and glycemic condition at any time-point (p > 0.05).

CONCLUSIONS:

The treatments did not differ with respect to clinical parameters, including the primary outcome variable (i.e. changes in clinical attachment level in deep pockets), for up to 12 months post-treatments.

• Authors: Vanessa R Santos, Jadson A Lima, Tamires S Miranda, Tiago E D Gonçalves, Luciene C Figueiredo, Marcelo Faveri, Poliana M Duarte
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 40 Issue 2 Pg. 155-62 (Feb 2013) ISSN: 1600-051X [Electronic] United States
• PMID: 23305133 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 John Wiley & Sons A/S.

Chemical References

• Anti-Infective Agents, Local
• Gels
• Glycated Hemoglobin A
• Chlorhexidine

Topics

• Adult
• Aged
• Analysis of Variance
• Anti-Infective Agents, Local (blood, therapeutic use)
• Chlorhexidine (therapeutic use)
• Chronic Periodontitis (complications, drug therapy)
• Dental Scaling
• Diabetes Mellitus, Type 2 (complications, drug therapy, metabolism)
• Female
• Gels
• Glycated Hemoglobin (analysis)
• Humans
• Male
• Middle Aged
• Periodontal Attachment Loss (pathology)
• Prospective Studies
• Single-Blind Method
• Statistics, Nonparametric
• Treatment Outcome