Abstract | AIM: To compare the 1-year clinical and microbiological outcomes of an enhanced anti-infective therapy with versus without systemic antimicrobials in patients with generalized aggressive periodontitis (GAP). METHODS: In this 12-month randomized, double-blinded, placebo-controlled trial, 35 individuals assigned to a control (n = 17) or test group (n = 18) received full-mouth supra and subgingival ultrasonic debridement followed by scaling and root planing with chlorhexidine rinsing, brushing, and irrigation. Subjects received either amoxicillin (AMX, 500 mg) + metronidazole (MET, 250 mg) or placebos, TID for 10 days. Subgingival samples were obtained and analysed for their composition by checkerboard. Data were subjected to non-parametric tests. RESULTS: Both therapeutic protocols resulted in similar significant clinical improvement for most parameters at 1 year (p < 0.01). The AMX + MET group exhibited shallower residual pockets than the placebo (p = 0.05). Most periodontal pathogens decreased, whereas beneficial bacteria increased in counts in both groups over time (p < 0.0012). High levels of some periodontal and other microbial pathogens were associated with disease persistence regardless treatment. CONCLUSIONS: The enhanced anti-infective mechanical therapy is comparable with its combination with systemic AMX+MET for most clinical parameters and for maintaining low levels of periodontal pathogens for up to 1 year after treatment of GAP.
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Authors | Mayra Xavier E Silva-Senem, Débora Heller, Victor Macedo Varela, Maria Cynesia Barros Torres, Eduardo Jorge Feres-Filho, Ana Paula Vieira Colombo |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 40
Issue 3
Pg. 242-51
(Mar 2013)
ISSN: 1600-051X [Electronic] United States |
PMID | 23297772
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | © 2012 John Wiley & Sons A/S. |
Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Drug Combinations
- Mouthwashes
- Placebos
- Metronidazole
- Amoxicillin
- Chlorhexidine
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Topics |
- Aggressive Periodontitis
(drug therapy, microbiology, therapy)
- Amoxicillin
(administration & dosage, therapeutic use)
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Anti-Infective Agents, Local
(administration & dosage, therapeutic use)
- Bacterial Load
(drug effects)
- Chlorhexidine
(administration & dosage, therapeutic use)
- Dental Scaling
(methods)
- Double-Blind Method
- Drug Combinations
- Follow-Up Studies
- Gram-Negative Bacteria
(classification, drug effects)
- Gram-Positive Bacteria
(classification, drug effects)
- Humans
- Metronidazole
(administration & dosage, therapeutic use)
- Mouthwashes
(administration & dosage, therapeutic use)
- Periodontal Debridement
(methods)
- Periodontal Pocket
(drug therapy, microbiology, therapy)
- Placebos
- Root Planing
(methods)
- Therapeutic Irrigation
- Toothbrushing
(methods)
- Treatment Outcome
- Ultrasonic Therapy
(methods)
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