[Resistance of mice to hypoxia of various types and to X-ray radiation in the post-hypoxic period].

Abstract

Resistance of mice to altitude, gas, hemic, tissue, mixed or hyperoxis hypoxia, to oxidative phosphorylation uncoupling agents and to X-ray irradiation during 2 days after exposure to severe acute hypobaric hypoxia was investigated. No significant changes were found in animal resistance to hemic and tissue hypoxia and to oxidative phosphorylation uncoupling agents. Resistance to hypoxic hypoxia was 2.5 times higher at the 2nd hour of the posthypoxic period and returned to the baseline by the 24 th hour. Resistance to sodium nitrite and potassium persulphate that cause hypoxia of mixed type, to hyperoxia and X-raying increased significantly by the 24th hour and returned to the baseline by the 48th hour of the posthypoxic period. The potential role of the antioxidative system in the induction of resistance to oxidative agents and X-ray irradiation during the posthypoxic period is discussed.

• Authors: Iu Iu Ivnitskiĭ, N Ia Moiseev
• Journal: Kosmicheskaia biologiia i aviakosmicheskaia meditsina (Kosm Biol Aviakosm Med) 1990 Jan-Feb Vol. 24 Issue 1 Pg. 32-4 ISSN: 0321-5040 [Print] Russia (Federation)
• Vernacular Title: Ustoĭchivost' mysheĭ k gipoksii razlichnogo tipa i rentgenovskomu izlucheniiu v postgipoksicheskiĭ period.
• PMID: 2329767 (Publication Type: Comparative Study, Journal Article)

Topics

• Acute Disease
• Adaptation, Physiological (physiology, radiation effects)
• Altitude Sickness (etiology, physiopathology)
• Animals
• Atmosphere Exposure Chambers
• Carbon Monoxide Poisoning (physiopathology)
• Hypoxia (etiology, physiopathology)
• Male
• Mice
• Radiation Dosage
• Radiation Tolerance (physiology)
• Time Factors