The effects of coenzyme A on serum lipids in patients with hyperlipidemia: results of a multicenter clinical trial.

Abstract

OBJECTIVES:

The aim of the study was to evaluate the lipid-lowering effects and clinical safety of a natural hypolipidemic compound, coenzyme A (CoA) capsule, in Chinese patients with moderate dyslipidemia.

METHODS:

A total of 244 subjects (170 males and 74 females; aged 18-75 y) having moderate dyslipidemia (triglyceride [TG], 2.3-6.5 mmol · L(-1)) were randomly divided into 3 groups, to which placebo (group A, n = 81), CoA 200 U/d (group B, n = 79), and CoA 400 U/d (group C, n = 84) were administered, respectively. Blood lipoproteins, liver and renal functions, blood glucose, and complete blood count were measured at the baseline and after 4 or 8 weeks of treatment.

RESULTS:

After treatment for 4 weeks, TG was reduced by 5.1, 15.7, and 14.4% in groups A, B, and C, respectively. After treatment for 8 weeks, TG decreased .9, 21.7, and 36.1%, respectively. Compared with group A, the primary efficacy outcome TG in groups B and C significantly decreased (P < .01), and the difference between groups B and C was also significant (P < .01). Plasma total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were not significantly different. Furthermore, there was no difference in blood glucose, hepatic and renal function test parameters, incidence of myopathy, or gastrointestinal tract symptoms among the 3 groups.

CONCLUSION:

CoA can effectively reduce plasma TG levels in subjects with moderate dyslipidemia and has no obvious adverse effect.

• Authors: Ya-qin Chen, Shui-ping Zhao, Jun-zhu Chen, Jiangtao Lai
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 98 Issue 2 Pg. E275-8 (Feb 2013) ISSN: 1945-7197 [Electronic] United States
• PMID: 23293333 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anticholesteremic Agents
• Blood Glucose
• Lipids
• Coenzyme A

Topics

• Adolescent
• Adult
• Aged
• Anticholesteremic Agents (pharmacology, therapeutic use)
• Blood Glucose
• Coenzyme A (pharmacology, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Hyperlipidemias (blood, drug therapy, physiopathology)
• Kidney (drug effects, physiopathology)
• Lipids (blood)
• Liver (drug effects, physiopathology)
• Male
• Middle Aged
• Treatment Outcome