Abstract | BACKGROUND:
Androgen receptor (AR) knockout male mice display hepatic steatosis, suggesting that AR signaling may regulate hepatic fat. However, the effects of testosterone replacement on hepatic fat in men are unknown. The aim of this study was to determine the effects of testosterone administration on hepatic fat in older men with mobility limitation and low testosterone levels who were participating in a randomized trial (the Testosterone in Older Men trial). METHODS: RESULTS: Baseline characteristics were similar between the two groups, including liver volumes (1583 ± 363 in the testosterone group vs 1522 ± 271 mL in the placebo group, p = .42). Testosterone concentrations increased from 250 ± 72 to 632 ± 363 ng/dL in testosterone group but did not change in placebo group. Changes in liver volume during intervention did not differ significantly between groups (p = .5) and were not related to on-treatment testosterone concentrations. The change in homeostatic model assessment- insulin resistance also did not differ significantly between groups and was not related to either baseline or change in liver fat. CONCLUSION:
Testosterone administration in older men with mobility limitation and low testosterone levels was not associated with a reduction in hepatic fat. Larger trials are needed to determine whether testosterone replacement improves liver fat in men with nonalcoholic hepatic steatosis.
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Authors | Grace Huang, Shalender Bhasin, Elizabeth R Tang, Adam Aakil, Stephan W Anderson, Hernan Jara, Maithili Davda, Thomas G Travison, Shehzad Basaria |
Journal | The journals of gerontology. Series A, Biological sciences and medical sciences
(J Gerontol A Biol Sci Med Sci)
Vol. 68
Issue 8
Pg. 954-9
(Aug 2013)
ISSN: 1758-535X [Electronic] United States |
PMID | 23292288
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adipose Tissue
(drug effects, pathology)
- Aged
- Aged, 80 and over
- Fatty Liver
(blood, drug therapy, pathology)
- Humans
- Insulin Resistance
- Liver
(drug effects, pathology)
- Magnetic Resonance Imaging
- Male
- Mobility Limitation
- Testosterone
(administration & dosage, blood, deficiency)
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