Psoriasis is associated with
obesity accompanied by
insulin resistance. A recent study disclosed increased plasma
resistin and decreased plasma omentin levels in
obesity. Few studies of plasma levels of
resistin and omentin are available in
psoriasis. We analyzed plasma levels of
resistin and omentin in
psoriasis and compared them with those of healthy controls. Evaluation of plasma levels of
resistin and omentin was performed by
enzyme-linked
immunosorbent assay (ELISA) for 62
psoriasis patients and 58 healthy controls. The severity of
psoriasis was evaluated by
psoriasis area and severity index (PASI) score. Plasma levels of
resistin were significantly increased in
psoriasis as compared with those of healthy controls. In contrast, plasma levels of omentin were significantly decreased in
psoriasis patients. Plasma levels of
resistin and omentin were positively and negatively correlated with PASI scores, respectively. After the treatment of
psoriasis,
resistin levels were decreased and omentin levels were increased, respectively, compared with those of pretreated. Plasma levels of
resistin and omentin might be useful for evaluating the disease activity of
psoriasis.