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Liver fatty acid-binding protein is a diagnostic marker to detect liver injury due to chronic hepatitis C infection.

AbstractBACKGROUND AND AIMS:
Liver fatty acid-binding protein (L-FABP) is a small molecule. The aim of this study was to examine L-FABP levels and to detect its diagnostic value in chronic hepatitis C (CHC).
METHODS:
We studied 22 patients with CHC and 20 healthy control subjects. Patients with persistently elevated serum aminotransferases and positive HCV RNA were included in the study. Patients with CHC underwent percutaneous liver biopsy. Serum level of L-FABP was determined by ELISA method.
RESULTS:
Patients with CHC had significantly increased levels of L-FABP compared to controls. A strong correlation between serum L-FABP concentrations and aspartate aminotransferases, alanine aminotransferases, HCV RNA levels and hepatic inflammation was found. When a cut-off value was 29,000 pg/mL for L-FABP, sensitivity and specificity were 75 and 100%, respectively. Positive and negative predictive values for L-FABP were 100 and 78%, respectively.
CONCLUSIONS:
Serum L-FABP is used as a new diagnostic marker to detect liver injury.
AuthorsErdem Akbal, Seyfettin Köklü, Erdem Koçak, Başak Cakal, Fahri Güneş, Omer Başar, Yaşar Tuna, Mehmet Senes
JournalArchives of medical research (Arch Med Res) Vol. 44 Issue 1 Pg. 34-8 (Jan 2013) ISSN: 1873-5487 [Electronic] United States
PMID23291381 (Publication Type: Journal Article)
CopyrightCopyright © 2013 IMSS. All rights reserved.
Chemical References
  • Biomarkers
  • Fatty Acid-Binding Proteins
  • RNA, Viral
  • Aspartate Aminotransferases
  • Alanine Transaminase
Topics
  • Adult
  • Alanine Transaminase (blood)
  • Aspartate Aminotransferases (blood)
  • Biomarkers (blood)
  • Case-Control Studies
  • Fatty Acid-Binding Proteins (blood, metabolism)
  • Female
  • Hepacivirus (genetics, isolation & purification)
  • Hepatitis C, Chronic (blood, pathology, virology)
  • Humans
  • Inflammation (blood, pathology, virology)
  • Liver (enzymology, metabolism, pathology)
  • Male
  • Middle Aged
  • RNA, Viral (analysis)
  • Sensitivity and Specificity

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