Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chronically infected cells.

Abstract

The anti-HIV-1 activity of GUT-70, a natural product derived from the stem bark of Chlophyllum brasiliense, was evaluated. GUT-70 inhibited HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. Our results strengthen the idea that NF-κB pathway is one of the potential targets to control HIV-1 replication and that GUT-70 could serve as a lead compound to develop novel therapeutic agents against HIV-1 infection.

• Authors: Eriko Kudo, Manabu Taura, Kouki Matsuda, Masako Shimamoto, Ryusho Kariya, Hiroki Goto, Shinichiro Hattori, Shinya Kimura, Seiji Okada
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 23 Issue 3 Pg. 606-9 (Feb 01 2013) ISSN: 1464-3405 [Electronic] England
• PMID: 23290051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antiviral Agents
• Coumarins
• GUT-70
• Protein Serine-Threonine Kinases
• NF-kappa B kinase

Topics

• Antiviral Agents (pharmacology)
• Cell Line
• Coumarins (chemistry, pharmacology)
• HIV Infections (virology)
• HIV-1 (drug effects)
• Humans
• Inhibitory Concentration 50
• Molecular Structure
• Protein Serine-Threonine Kinases (antagonists & inhibitors)
• Virus Replication (drug effects)