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Effectiveness of teriparatide treatment on back pain-related functional limitations in individuals affected by severe osteoporosis: a prospective pilot study.

AbstractINTRODUCTION:
Vertebral fractures have been associated with back pain, functional limitations and reduced health-related quality of life (HRQoL). Teriparatide is the first effective anabolic agent that demonstrated to significantly reduce the risk of vertebral fracture by 65%, as compared to placebo. The aims of this study were to evaluate the effectiveness of teriparatide treatment on back pain-related functional limitations and to investigate on patients HRQoL.
MATERIALS AND METHODS:
In this prospective observational pilot study osteoporotic patients, who were prescribed teriparatide therapy and a supplementation of calcium and vitamin D, were asked to answer to two self-administered questionnaires: the Spine Pain Index (SPI) and the SF-12 (at the recruitment, after 6, 12, and 18 months).
RESULTS:
Fifty-two women were evaluated (mean age of 70.58 yrs). The mean SPI score passed from 50.01 at baseline to 32.20 at 18 months. The mean SF-12 PCS score passed from 30.00 at baseline to 36.79 at 18 months, while the mean SF-12 MCS score was already within the normality range at baseline, constantly improving during the 18 months.
CONCLUSION:
In conclusion, 18 months of treatment with teriparatide has to be considered an effective therapeutic option for women with severe osteoporosis and vertebral fractures, in a real-life clinical setting, to improve both back pain related disability and quality of life.
AuthorsGiovanni Iolascon, Francesca Gimigliano, Nazzarena Malavolta, Umberto Tarantino, Rachele Fornari, Emanuela Greco, Gioconda Di Pietro, Raffaele Gimigliano, Andrea Lenzi, Giuseppina Resmini, Silvia Migliaccio
JournalClinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases (Clin Cases Miner Bone Metab) Vol. 9 Issue 3 Pg. 161-5 (Sep 2012) ISSN: 1724-8914 [Print] Italy
PMID23289031 (Publication Type: Journal Article)

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